| 货号 | APC-052-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to HCN4 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and have a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity.1,2 The Ih currents are generated by the Hyperpolarization-activated cyclic nucleotide-gated channel family ( Each The The channels are closely related to each other and share a homology of about 60%. However, their similarity decreases in the cytoplasmic N- and C-termini. The HCN4 is highly expressed in a restricted manner in adult sinoatrial (SA) node, constituting a good molecular marker for the adult cardiac pacemaker and might serve as a unique marker of the developing SA node .4,5 mRNA expression of HCN4 is most abundant in medial habenula and anterior and principal relay nuclei of the thalamus.6 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | The serum was depleted of anti-GST antibodies by affinity chromatography on immobilized GST, and then anti-HCN4 antibody was affinity purified on immobilized HCN4-GST. |
| 参考文献 | 1.Much, B.et al(2003)J.Biol.Chem.278,43781. 2.Notomi, T. and Shigemoto R. (2004)J. Comp. Neurol.471,241. 3.Gravante, B.et al(2004)J.Biol.Chem.279,43847. 4.Moosmang, S.et al.(2001)Eur. J. Biochem.268,1646. 5.Garcia-Frigola, C. et al. (2003) Gene Expr Patterns3,777. 6.Monteggia, L. et al. (2000) Molec. Brain Res. 1-2,129. |
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