| 货号 | APC-035-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Kir4.1 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | Kir4.1 is a member of the inward rectifying K+ channel family. The family includes 15 members that are structurally and functionally different from the voltage-dependent K+ channels. The family’s topology consists of two transmembrane domains that flank a single and highly conserved pore region with intracellular N- and C-termini. As is the case for the voltage-dependent K+ channels the functional unit for the Kir channels is composed of four subunit that can assembly as either homo or heteromers. Kir channels are characterized by a K+ efflux that is limited by depolarizing membrane potentials thus making them essential for controlling resting membrane potential and K+ homeostasis. Kir4.1 is a member of the Kir4 subfamily that includes one other member: Kir4.2. Kir4.1 can co-assemble with Kir4.2 but also with other Kir channels such as Kir2.1andKir5.1. The Kir4 subfamily has been classified as weak rectifiers with intermediate conductance. Kir4.1 is mainly expressed in brain, specifically in glia cells, but also in retina, ear and kidney.1,2 It has been proposed that Kir4.1 has an essential role in glial K+ buffering, a process that re-uptakes the K+released during neuronal activity into the intracellular interstitial space. Loss of Kir4.1 causes retinal defects and loss of endochoclear potential.3 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Takumi, T.et al. (1995)J. Biol. Chem.270,16339. 2.Higashi, K. et al.(2001)Am. J. Physiol. 281,C922. 3.Butt, A.M. and Kalsi, A.(2006)J. Cell Mol. Med.10,33. |
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