| 货号 | APC-022-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to KV7.1 (KCNQ1) Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | KV7.1 (KCNQ1) is part of a voltage-gated K+ family that includes 5 other members (KCNQ1-5). The channel has been intensively studied since it was found that together with MinK (Isk) it underlay the cardiac Iks current that controls the duration of the action potential of the human heart. Indeed mutations on either KV7.1 or MinK can be responsible for long QT syndrome, a cardiac disorder that causes arrhythmias and sudden death. Although KV7.1 expression and function has been mainly investigated in relation with cardiac function the channel is widely distributed in epithelial tissues. There it has been implicated in physiological functions such as: regulation of acid secretion in the stomach and Cl- secretion into the colon. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wang, Q.et al.(1996)Nat. Genet. 12,17. 2.Grahammer, F.et al.(2001)Gastroenterology120,1363. 3.Mall, M.et al.(1998)Am. J. Physiol. 275,G1274. |
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