| 货号 | ANT-131-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to MATE1 |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | MATE1 (SLC47A1) and MATE2 (SLC47A2) are multidrug and toxin extrusion transporter 1 and 2 function as cationic pumps in the kidneys, liver, and intestine1. Both MATEs excrete molecules with a positive net-charge from renal tubular epithelial cells in the kidney (where they are co-expressed with organic anion- and cation-transporters; OATs and OCTs), and into the urine. In the liver, MATE1, but not MATE2, regulates the transportation of tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP) – again, by cation-powered pumps2. Fairly recent X-ray crystallography has revealed that mammalian MATE1 has 13 transmembrane helices and a long cytoplasmic tail. Cysteine and histidine residues are responsible for the protein's functionality1. Overexpression of MATE1 is helpful in the delivery of metal-based anti-cancer drugs, such as cisplatin and oxaliplatin, as it effectively accumulates platinum intracellularly3. Furthermore, a rare increase in copy number of MATE1 in maize protects the plant from aluminum (Al) toxicity4. On the other hand, inhibition of MATE1 may lead to potentially dangerous drug-drug interactions, due to damaged drug extrusion regulation5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 参考文献 | 1.Lee, J.H.et al. (2014) J. Agric. Food Chem.62,9690. 2.Wright, S.H.et al.(1995)Pflugers Arch. Eur. J .Physiol.429,313. 3.Jong N.N. and McKeage, M.J.(2014)Biopharm. Drug Dispos. doi: 10.1002/bdd.1903. 4.Maron, L.G.et al.(2013)Proc. Natl. Acad. Sci. U.S.A.110,5241. 5.Wittwer, M.B. et al. (2013) J. Med. Chem. 56,781. |
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