| 货号 | ANT-103-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Cationic amino acid transporter 2 |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | The cationic amino acid transporter (CAT) family is comprised of four homologous membrane proteins: CAT-1, CAT-2, CAT-3 and CAT-4, encoded by the Slc7A1−4 genes, respectively. The major difference between these transporters is at the level of tissue specificity and regulation of their expression1,2. The CAT family is included in the Na+-independent transport system, (named system y+) that mediate L-arginine uptake in most tissues and cells3. CAT-2 is known to transport cationic amino acids such as L-arginine, L-ornithine, and L-lysine. It is considered to be the major arginine transporter in most cells and tissues. It can be expressed in two spliced variants, CAT-2A and CAT-2B. CAT-2A, is a low-affinity transporter, constitutively expressed in the liver and muscle cells, whereas CAT-2B, is a high-affinity transporter, abundantly expressed in macrophages3. Macrophages isolated from mice deficient in CAT-2 show impaired ability to transport arginine intracellularly and to produce nitric oxide in response to endotoxin thus, CAT2 may also be important in regulating immune cell function in inflammation4. Studies have identified CAT2 as a regulator of fibrotic responses in the lung5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Sans-Fons, M.G.et al.(2013)J. Infect Dis. 207,93. 2.Wanasen, N. and Soong, L.(2008)Immunol. Res.41,15. 3.King, N.E.et al.(2004)J. Nutr.134,2830. 4.Scumpia, P.O.et al.(2002)Am. J. Physiol.283,1231. 5.Niese, K.A.et al.(2010)Respir. Res. 11,87. |
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