| 货号 | ANT-007-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Human p75NTR |
| 反应种属 | H, M, R |
| 应用 | IC, IFC, IH, IP, LCI, WB |
| 供应商 | Alomone |
| 背景 | The p75NTR receptor is a member of the TNF receptor superfamily. p75NTR, like all the superfamily members is a type I transmembrane protein with tandem cysteine-rich domains in the extracellular portion and a intracellular death domain. p75NTR binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA,TrkB,TrkC,Nogo receptorandsortilin. The precise multimeric receptor complex formed between p75NTR and the other receptors will determine the ligand being recognized (see below) and the biological response to its binding. As it name implies, p75NTR binds all the neurotrophins(NGF,BDNF,NT-3andNT-4) with similar nM affinities. Co-expression of p75NTR with the Trk receptors enhances the ability to bind and respond to the specific neurotrophin and induces cell survival. On the other hand, it has recently been demonstrated that p75NTR binds with high affinity to the unprocessed form of NGF (proNGF) probably as a complex with sortilin and this leads to cell death by apoptosis. Finally, a multimeric complex of p75NTR and Nogo receptor binds myelin proteins such as Nogo-66, MAG and OmgP resulting in inhibition of axonal growth. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Hempstead, B.L.(2002)Curr. Opin. Neurobiol. 12,260. 2.Chao, M.V. (2003)Nat. Rev. Neurosci. 4,299. 3.Barker, P.A. (2004)Neuron42,529. |
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