| 货号 | ANR-072-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to NMU2 Receptor |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Neuromedin U (NMU) is a highly conserved, ubiquitously distributed neuropeptide, which regulates food intake and body weight. Two high-affinity receptors have been identified for NMU: Neuromedin U receptor 1(NMUR1) and Neuromedin U receptor 2 (NMUR2) that belong to the G-protein coupled receptors (GPCRs). These receptors are members of the rhodopsin-like class A G-protein coupled receptors family and share about 50% identity with each other in the seven transmembrane region. NMUR2 is highly expressed in the central nervous system, in the paraventricular nucleus of the hypothalamus, nuclei accumbens, hippocampus, thalamus, medulla oblongata, and spinal cord. It is also detected in organs such as the uterus and ovary, and is abundant in nociceptive sensory pathways, including spinal dorsal horn, dorsal root ganglia, thalamus, and brain stem1-5. Central effects of NMU including the regulation of food intake, energy balance, stress response, and nociception are mediated by NMUR2. In the brain, NMUR2 is predominant in the hypothalamic regions that are associated with regulation of food intake and energy balance5. NMUR2 receptor has been suggested to be used as a potential target for developing new therapeutics for the treatment of eating disorders, obesity, stress-related disorders, and pain5. Some studies have demonstrated that NMUR2 signaling in the paraventricular nucleus of the hypothalamus regulates consumption and preference for high-fat foods2. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Brighton, P.J.et al.(2004)Pharmacol. Rev. 56,231. 2.Benzon, C.R.et al.(2014)Neuroscience 258,270. 3.Lin, T.Y.et al.(2013)Am. J. Physiol. Endocrinol. Metab.304,8. 4.Zeng, H.et al.(2006)Mol. Cell. Biol.26,9352. 5.Liu, J.J.et al.(2009)J. Pharmacol. Exp. Ther. 330,268. |
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