| 货号 | ANR-041-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Neural Cell Adhesion Molecule 1 |
| 反应种属 | H, M, R |
| 应用 | IC, LCI, WB |
| 供应商 | Alomone |
| 背景 | Neural cell adhesion molecule 1 (NCAM1) is a member of a large family of cell-surface glycoproteins and plays a major role during development and controls various functions in the nervous system such as: cell migration, neurite growth, axonal guidance, and synaptic plasticity1. NCAM1 mediates adhesion between cells through homophilic bonds formed between its extracellular domains, which comprise five tandem Ig domains and two juxtamembrane fibronectin type III (Fn III) domains2. There are three major protein isoforms of NCAM1: 180 kd, 140 kd, and 120 kd. The 180-kd and 140-kd isoforms of NCAM1 are transmembrane proteins, whereas the 120-kd isoform is linked to the plasma membrane via a glycosyl phosphatidyl-inositol (GPI) lipid anchor3. NCAM1 is widely expressed in the central nervous system, skeletal muscle and natural killer cells4. Several lines of evidence have supported the idea that dysregulation of NCAM1 isoforms in the brain might be involved in the pathophysiology of neuropsychiatric disorders, particularly bipolar affective disorder5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Johnson, C.P. et al.(2004) Proc. Natl. Acad. Sci. U.S.A.101,6963. 2.Lanier, L.L.et al.(1991)J. Immunol.146,4421. 3.Kiss, J.Z. and Muller, D.(2001)Rev. Neurosci.12,297. 4.Arai, M. et al. (2004) Biol. Psychiatry55,804. 5.Ćirović, S.et al. (2014) Int. J. Clin. Exp. Pathol.7,1402. |
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