| 货号 | ANP-001-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to α 1 Na+/K+ ATPase |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Na+/K+-ATPase a membrane protein located on the plasma membrane of all animal cells, is involved in maintaining the Na+ and K+ gradient across the cell membrane1. It is ubiquitously expressed in neurons and helps maintain normal neuronal function2. The enzyme is composed of a catalytic a chain of 112 kDa. and α glycosylated β chain of 40–50 kDa.3. There are four isoforms of the α subunit (α1, α2, α3 and α4) and three isoforms of the β subunit (β1, β2 and β3) with different tissue distributions4. The N-terminus is on the cytoplasmic side of the membrane, four transmembrane segments in the first third of the polypeptide chain, a large cytoplasmic loop (LCL) comprising the second third of the chain and four to six transmembrane segments in the C-terminal third of the protein with the C-terminus on the cytoplasmic side of the membrane5. Na+/K+-ATPase abnormalities have been reported to be involved in several neurological diseases such as seizures, bipolar disorder, spongiform encephalopathy, and Alzheimer’s disease. Na+/K+-ATPase may also have implications in behavioral defects6. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Goldin, S.M.et al. (1977) J. Biol. Chem.252,5630. 2.Jorgensen, P. L. and Andersen, J.P.(1988)J. Membr. Biol.103,95. 3.Pietrini, G.et al.(1992)Proc. Natl. Acad. Sci. U.S.A.89,8414. 4. Guidotti, G. et al.(1990)Chemtracts: Biochem. Mol. Biol.1,447. 5.Yoon, K. L. and Guidotti, G.(1994)J. Biol. Chem.269,28249. 6.Ji, L.et al.(2009)Life Sci.85,788. |
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