| 货号 | AMT-012-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to MCT2 Transporter |
| 反应种属 | M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | The SLC16A family of monocarboxylate transporters (MCTs) is composed of 14 members. MCTs play a central role in cellular metabolism and metabolic communication between tissues. The rapid transport of monocarboxylates such as pyruvate, lactate, and ketone bodies (acetoacetate and β-hydroxybutyrate) across the plasma membrane of cells is facilitated by proton-linked MCTs1. MCTs share similarities in sequence and protein structure, but each member differs from others in the substrates that they transport. For example, lactate among other monocarboxylates, is the primary substrate for MCT1, MCT2, MCT3 and MCT42. All family members are predicted to have 12 transmembrane helices (TMs) with intracellular C- and N-termini as well as a large cytosolic loop3. MCT2 is distributed in testis, brain, skeletal muscle, heart, and kidney4. MCTs are important for normal metabolic function and are implicated in disease. Changes in the cerebral density of MCT2 have been reported acutely following hypoxia-ischemia in vivo and in hippocampal slices5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Lin, R.Y.et al.(1998)J. Biol. Chem.273,2895. 2.Adijanto, J. and Philp, N.J.(2012)Curr. Top. Membr.70,275. 3.Halestrap, A.P.(2012)IUBMBLife64,1. 4.Wang, Q.et al.(2007)Drug Metab. Dispos.35,1393. 5.Prins, M.L. Giza, C.C.(2006)Dev. Neurosci.28,447. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |