| 货号 | ALR-035-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to LPA5 Receptor |
| 反应种属 | H |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | LPA (lysophosphatidic acid) mediates cellular differentiation, growth, survival and motility through two subgroups of G-protein coupled receptors (GPCRs): The Edg (endothelial differentiation gene) family – LPA1, LPA2, LPA3 and the non-Edg family – LPA4, LPA5, LPA61. Like all GPCRs, LPA receptors have seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail1. Alkyl-LPA, commonly found in platelets activates LPA5, thus explaining the high expression of the receptor in platelets2. LPA is expressed in astrocytes, and sensory and motor neurons in the spinal cord. It is also detected in spleen, heart, placenta, lliver and colon3. LPA5 activation leads to cAMP production; however, it does so in a Gs independent manner4,5. The receptor couples Gq, thus leading to Ca2+mobilization4. Activation of LPA5 was also shown to initiate neuropathic pain in mouse models. LPA5 knockout mice do not develop neuropathic pain6. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Yanagida, K.et al.(2013)Biochim. Biophys. Acta1831,33. 2.Amisten, S.et al.(2008)Thromb. Res.122,47. 3.Mutoh, T.et al.(2012)Br. J. Pharmacol.165,829. 4.Lee, C.W.et al.(2006)J. Biol. Chem.281,23589. 5.Jongsma, M.et al.(2012)PLoS ONE6,e29260. 6.Lin, M.E.et al.(2012)J. Biol. Chem.287,17608. |
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