| 货号 | ALR-034-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to LPA4 Receptor |
| 反应种属 | M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Lysophosphatidic acid (LPA) is a bioactive lipid molecule with a phosphate, a glycerol, and a fatty acid in its structure. The cellular effects of LPA include proliferation, migration, cytokine secretion, and morphological change. These pleiotropic actions allow LPA to participate in a wide variety of biological processes, such as brain development, oncogenesis, wound healing and cancer progression1. To date, at least 6 subtypes of LPA receptor have been identified. The LPA1–3 receptors are members of the endothelial cell differentiation gene (Edg) family. LPA4, a member of the purinergic receptor family, and the recently identified LPA5 are structurally distant from the canonical Edg LPA1–3 receptors. LPA4 and LPA5 are linked to Gq, G12/13 and Gs but not Gi, while LPA1–3 all couple to Gi in addition to Gq and G12/132. LPA4 (p2y9/GPR23) was cloned as an orphan GPCR and is closely related to the purinergic P2Y receptors3. Like all GPCRs it has seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs); the N-terminus is on the extracellular side of the membrane, and the C-terminus is on the cytoplasmic side4. LPA4 is weakly expressed; there are high levels only in ovary2. LPA4-deficient mice display abnormalities in the blood vascular systems, which caused lethality of embryos and neonates5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Gendaszewska-Darmach, E.(2008)Acta Biochim. Pol.55,22. 2.Noguchi, K.et al. (2003)J.Biol. Chem.278,25600. 3.Yanagida, K. and Ishii, S.(2011)J. Biochem.150,223. 4.Oh, D.Y.et al. (2006) Int. Rev. Cytol.252,163. 5.Sumida, H.et al.(2010)Blood116,1. |
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