| 货号 | ALR-023-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to GP130 |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Interleukins (ILs) are key mediators in the regulation and coordination of the immune response. Glycoprotein 130 (gp130) belongs to the family of class I cytokine receptors and is the common signal transducing receptor subunit of the IL-6-type cytokines: IL-6, IL-11, leukemia inhibitory factor(LIF),ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and cardiotrophin-11.The inflammatory cytokines IL-6 and IL-11 induce gp130 homodimerization after binding to their specific α receptors, which leads to the activation of the Janus kinase/STAT signal transduction pathway2. Gp130 Heterodimerizes with LIFR in response to LIF, CNTF, OSM, or CT13. The extracellular part of gp130 contains an Ig-like domain (D1) followed by single cytokine binding module (CBM) (D2 and D3) and three fibronectin type III-like (FNIII) domains (D4, D5, and D6)3. Gp130 mRNA is ubiquitously expressed in the human body, exhibiting highest levels in saphenous vein, pericardium, ovary, omental adipose tissue, peritoneum, spleen lymph nodes, and trigeminal ganglia4. Dysregulation of gp130 expression, activation, or associated signaling pathways are implicated in a variety of human diseases including cancer, rheumatoid arthritis, Castleman’s disease, cardiac myxoma, Crohn’s disease, psoriasis, asthma, amyotrophic lateral sclerosis (CNTF), diabetes, atherosclerosis, systemic lupus, obesity, and postmenopausal osteoporosis5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Kurth, I.et al.(2000)J. Immunol.164,273. 2.Kurth, I. et al. (1999) J. Immunol. 162,1480. 3.Timmermann, A.et al. (2002) Eur. J. Biochem.269,2716. 4.Xu, S.et al. (2013)Expert Opin. Ther. Targets17,1303. 5.Jones, S.A.et al. (2011) J. Clin. Invest.121,3375. |
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