| 货号 | AKT-001-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to KCC1 Transporter |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Potassium chloride cotransporters (KCCs) are members of cation chloride cotransporter gene superfamily (Slc12 family). This family consists of sodium potassium two chloride cotransporter 1 (NKCC1) and 2 (NKCC2), sodium chloride cotransporte (NCC) and KCCs1. All of these transporters mediate electroneutral transport of cations coupled with one or two Cl- and contribute to regulation of cell volume and homeostasis of intracellular Cl- concentration. KCCs extrude one K+ with one Cl- from intracellular space to the extracellular space by using the chemical gradient of K+ as the driving force of Cl-extrusion2. Four KCC isofroms (KCC1, KCC2, KCC3 and KCC4) have been identified in mammalian species 3. K-Cl cotransporters regulate neuronal and glial electrochemical equilibrium potential for Cl-, and so can determine the excitatory or inhibitory influences of GABA- and glycine-gated Cl-channels4. KCC1 is a member of the cation-chloride cotransporter (CCC) superfamily of proteins, as with all CCC proteins, KCC1 is an integral membrane protein with 12 transmembrane domains and both N- and C-terminal cytoplasmic domains5. KCC1 is ubiquitously expressed6. K-Cl cotransport activity is elevated in red blood cells of individuals with sickle cell disease, thalassemia, and diseases associated with other mutant Hb. Human erythrocytes from individuals with the reticulocytotic anemic states of sickle cell disease, Hb SC disease, and β-thalassemia intermedia exhibit uniformly elevated KCC1-like immunoreactivity compared with normal AA erythrocytes 7. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Russell J.M.(2000)Physiol.Rev.80,211. 2.Nagao, H.et al.(2012)Cell. Physiol. Biochem.30,538. 3.Gamba, G.(2005)Physiol. Rev.85,423. 4.Delpire, E. and Gagnon, K.B.(2008) Biochem. J.409,321. 5.Lee, H.H.et al.(2007) J. Biol. Chem.282,29777. 6.Gillen, C.M.et al.(1996)J. Biol. Chem.271,16237. 7.Olivieri, O.et al. (1992) Blood79,793. |
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