| 货号 | AGT-006-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Taurine Transporter |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Taurine (2-aminoethane-sulfonice acid) is one of the most abundant amino acids found in the human body. It is involved in cell regulation and modulates the concentration of intracellular free calcium. It also plays a substantial role in many other functions varying from neurotransmition in the central nervous system to promotion of cell differentiation in the brain and also cytoprotection against oxidative stress1. Taurine is not used for protein synthesis, and in addition to its uptake in nutrition it can be synthesized in pancreatic mammalian cells by cysteine dioxygenase and sulfinoalanine decarboxylase enzymes2. Taurine is found mainly in organs such as the brain, retina and muscle tissue and other tissues as well. The uptake of taurine is conducted through the Taurine transporter (TauT). This energy for passage through the transporter is derived by Na+ and Cl- concentration similar to the uptake of other amino acids3. Taurine transporter also transports GABA, albeit with a lower affinity. The transporter has twelve transmembrane domains and intracellular N- and C-termini. Taurine transporter expression is regulated by cAMP which was found to increase its regulation in MDCK cells and also by PKC via means of post-translational modification. PKC activation leads to reduced taurine transport4. PKC is believed to phosphorylate the highly conserved serine-322 position in the transporter. Taurine deficiency is linked to cardiomyopathies in the hearts of cats and to a decrease in cardiac muscle sensitivity to calcium5 and better understanding of its transport may improve research of these diseases. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Ripps, H. and Shen, W.(2012)Mol. Vis.18,2673. 2.Bondareva, O.M.et al.(2008)Pharm. Chem. J. 42,142. 3.Zelikovic, I. and Chesney, R.H.(1989)Kidney Int. 36,351. 4.Han, X.et al.(1996)J. Am. Soc. Nephrol. 7,2088. 5.Schaffer, S.W.et al. (2010)J. Biomed. Sci.17,S2. |
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