| 货号 | AGT-001-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to GABA Transporter 1 (GAT-1) |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | γ-aminobutiric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Transmission via GABA can be halted by its reuptake through GABA transporters (GATs). These membrane proteins belong to the super family of slc6 genes which encode transporters responsible for the uptake of dopamine, serotonin, norepinephrine, glycine and GABA in a Na+-dependent manner1,2. To date, four GATs have been identified: GAT-1, GAT-2,GAT-3andBGT-1. Like all members of the slc6 family, they have twelve transmembrane domains and short intracellular N- and C-termini1. GATs couple the transport of one GABA molecule to 2Na+ ions and one Cl- ion3. GAT-1 activity can be regulated at the level of its plasma membrane expression which is in part regulated by its trafficking via phosphorylation of residues in intracellular loops1. GAT-1 expression is restricted to the central nervous system, specifically to axon terminals, in the neocortex and in some astrocytic processes4. GAT-1 may be implicated in various psychological and neurological disorders such as schizophrenia, epilepsy and cerebral ischemia1,5-7. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1. Gonzalez-Burgos, G. (2010) Adv. Pharmacol.58,175. 2. Gether, U. et al.(2006)Trends Pharmacol.Sci.27,375. 3. Meinild, A.K. et al.(2009)J. Biol. Chem.284,16226. 4. Conti, F. et al.(2011)Front. Cell. Neurosci.5,1. 5. Lewis, D.A. et al.(2005)Nat. Rev. Neurosci.6,312. 6. Fueta, Y. et al.(2003)Neuroscience118,371. 7. Frahm, C. et al.(2004)NeuroReport15,9. |
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