| 货号 | AGP-053-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Guinea Pig Polyclonal Antibody to ASIC1 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | ASIC1 is a member of a family of Na+ channels that are activated by external protons. The family includes another three members ASIC2,ASIC3andASIC4. The ASICs are in fact part of a larger superfamily termed epithelial Na+ channels (EnaC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. There are two recognized splice variants of the ASIC1 gene that differ on their N-termini, ASIC1a and ASIC1b that have different tissue distributions and functions. The ASIC1 responds to a decrease in extracellular pH with an inward cation current that is quickly inactivated despite the continuous presence of protons in the medium. Lately, ASIC1 has been implicated in processes such as learning and memory in the central nervous system. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Kellenberger, S. et al. (2002) Physiol. Rev. 82, 735. 2.Wemmie, J. A. et al. (2002) Neuron 34, 463. 3.Wemmie, J. A. et al. (2003) J. Neurosci. 23, 5496. |
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