| 货号 | AGP-043-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Guinea Pig Polyclonal Antibody to NaV1.1 Channel |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability1. Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.94,5. The NaV channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9)2,3. Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Na+ channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas Na+ channels in adult skeletal muscle have only the β1subunit6,7. NaV1.1 is a tetrodotoxin-sensitive channel and is broadly expressed in neurons7. Mutations in NaV1.1 are associated with at least two forms of epilepsy. Gain-of-function missense mutations are a primary cause of generalized epilepsy with febrile seizures plus (GEFS+). Loss-of-function mutations cause severe myoclonic epilepsy of infancy (SMEI) 8,9. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wu, L. et al. (2002) NeuroReport 13, 2547. 2.Fang, X. et al. (2002) J. Neurosci. 22, 7425. 3.Fjell, J. et al. (2000) NeuroReport 11, 199. 4.Baker, M.D. et al. (2001) Trends Pharmacol. Sci. 22, 27. 5.Lai, J. et al. (2003) Curr.Opin. Neurobiol 13, 291. 6.Isom, L.L. (2001) Neuroscientist 7, 42. 7.Catterall, W.A. et al. (2003) Pharmacol Rev 55, 575. 8.Catterall, W.A. et al. (2008) J. Neurosci. 28, 11768. 9.Rhodes, T.H. et al. (2004)Proc. Natl. Acad. Sci. U.S.A. 101, 11147. |
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