| 货号 | AGC-039-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Glutamate Receptor γ2 (GluD2) |
| 反应种属 | H, M, R |
| 应用 | IC, LCI, WB |
| 供应商 | Alomone |
| 背景 | Excitatory neurotransmission in the vertebrate central nervous system is mainly mediated by ionotropic glutamate receptors (iGluRs). Molecular cloning identified 18 mammalian iGluR subunits, of which only 16 sort into the traditional pharmacological subfamilies of AMPA, kainate (KA), and N-methyl-D-aspartate (NMDA) receptors. The 2 remaining subunits were termed “orphan” receptors, “glutamate-like” receptors, “nonionotropic” receptors, or, most commonly, delta receptors1. Ionotropic glutamate receptors are integral membrane proteins composed of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the δ receptors, suggests they share a similar architecture. Glutamate receptor subunits are modular structures that contain four discrete semiautonomous domains: the extracellular amino-terminal domain (ATD), the extracellular ligand-binding domain (LBD), the transmembrane domain (TMD), and an intracellular carboxyl-terminal domain (CTD)2. The delta family of ionotropic glutamate receptors (iGluRs) consists of the glutamate δ1 (GluD1) and glutamate δ2 (GluD2) receptors3. GluD1 is highly expressed in the inner hair cells of the organ of Corti4, diffusely expressed throughout the forebrain during development with high levels in the hippocampus during adulthood3. Deletion of GluD1 leads to a deficit in high frequency hearing in mice5. Genetic association studies have established the GRID1 gene, which codes for GluD1, is a strong candidate gene for schizophrenia, bipolar disorder, and major depressive disorder6. Copy number variation studies have also implicated GRID1 in autism spectrum disorder (ASD)7. In addition, GRID1 gene is localized to the 10q22-q23 genomic region which is a site for recurrent deletions associated with cognitive and behavioral abnormalities8. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Schmid, S. M. et al. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 10320. 2.Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. 3.Lomeli, H. et al. (1993) FEBS Lett. 315, 318. 4.Safieddine, S. and Wenthold, R.J. (1997) J. Neurosci. 17, 7523. 5.Gao, J. et al. (2007) Mol. Cell Biol. 27, 4500. 6.Treutlein, J. et al. (2009) Schizophr. Res. 111, 123. 7.Smith, M. et al. (2009) Ann N Y Acad Sci 1151, 102. 8.Balciuniene, J. et al. (2007) Am. J. Hum. Genet. 80, 938. |
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