| 货号 | AGA-020-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to GABA(A) ρ3 Receptor |
| 反应种属 | M, R |
| 应用 | IC, LCI, WB |
| 供应商 | Alomone |
| 背景 | γ-Aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter. It is involved in roughly 40% of the inhibitory synapses1,2. GABA acts through two receptors, GABA(A)andGABA(B). To date, nineteen different GABA(A) subunits have been identified and divided in eight subunits: α (1-6), β (1-3), γ (1-3), δ, ε, ρ (1-3), θ and π. For some of the subunits, alternative splicing further increases the number of existing receptor types. They all have extracellular N- and C-termini and four transmembrane domains1. Three ρ subunits have been detected: GABA(A) ρ1,GABA(A) ρ2 and GABA(A) ρ3. Like all GABA(A) receptors the ρ subunits also assemble into a pentameric structure forming a Cl- channel. However, in contrast to all other GABA(A) subunits they mostly form homomeric entities. The GABA(A) ρ subunits display different pharmacological characteristics and were therefore once referred to GABA(C) receptors. GABA(A) and GABA(B) respectively respond to bicuculline and baclofen, whereas ρ subunits are insensitive to either drug3-7. In addition, ρ subunits also display different electrophysiological properties, and are significantly more sensitive to GABA3,5,6,8. ρ subunits are highly expressed in the retina and it was believed that they are only expressed in that area. They are however, also expressed in central and peripheral nervous systems, as well as in the gastrointestinal and cardiovascular systems1. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Martinez-Delgado, G. et al. (2010) Curr. Neuropharmacol. 8, 422. 2.Kumar, R.J. et al. (2008) J. Med. Chem. 51, 3825. 3.Bormann, J.(2000) Trends Pharmacol. Sci. 21, 16. 4.Tortella, F.C.et al.(1989) Trends Pharmacol. Sci. 10, 501. 5.Johnston, G.A.(1996) Trends Pharmacol. Sci. 17, 319. 6.Bormann, J. and Feigenspan, A.(1995) Trends Neurosci. 18, 515. 7. Cherubini, E. and Strata, F. (1997) News Physiol. Sci. 12, 136. 8.Polenzani, L. et al. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 4318. |
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