| 货号 | AGA-003-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to GABA(A) α3 Receptor |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, LCI, WB |
| 供应商 | Alomone |
| 背景 | The neurotransmitter GABA (γ-aminobutiric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells.1 Binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance that results in inhibition of neural activity.2 There are two major types of GABA receptors: the ionotropic GABAA receptors (GABAAR) and the metabotropic GABAB receptors(GABABR). GABAARs belong to the ligand-gated ion channel superfamily.1,2 GABAARs are heteropentamers, in which all five subunits contribute to formation of the pore. Eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ.1 Six α subunits isoforms (α1-α6) have been shown to exist in mammals. In most cases, the native GABAA receptors consist of 2α, 2β, and 1γ subunits. The α3-subunit is highly expressed during development (along with α2 and α5) and then declines in adulthood, where the α1-subunit becomes predominant. The failure to complete this switch could be a major predispositional factor in the development of temporal lobe epilepsy.3 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Mihic, S.J. and Harris, R.A. (1997)Alcohol Health Res. World21, 127. 2.Whiting, P.J. (1999)Neurochem. Int. 34,387. 3.Fuchs, K. and Celepirovic, N.. (2002) J. Neurochem.82,1512. |
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