| 货号 | ACP-005-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to PMCA1 pump |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells responsible for removing calcium (Ca2+) from the cell. This pump is vital for regulating the amount of Ca2+ within cells1. PMCA and the Na+ calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations2. Since it transports Ca2+ into the extracellular space, PMCA is also an important regulator of the Ca2+ concentration in the extracellular space3. PMCA belongs to a family of P-type primary ion transport ATPases, and is expressed in a variety of tissues, including the brain4. The pump is powered by the hydrolysis of adenosine triphosphate (ATP), with a stoichiometry of one Ca2+ ion removed for each molecule of ATP hydrolyzed. It binds to Ca2+ ions with a high affinity (a Km of 100 to 200 nM) but does not remove Ca2+ at a very fast rate. This is in contrast to NCX, which has a low affinity and a high capacity. Thus, PMCA is effective at binding Ca2+ even when its concentration within the cell is very low, so it is suited for maintaining Ca2+ at its normally very low levels. The NCX is better suited for removing large amounts of Ca2+ quickly, as it is needed in neurons after an action potential. Thus the activities of the two types of pump complement each other5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Jensen, T.P. et al. (2004) Brain Res. Dev. Brain Res. 152, 129. 2.Strehler, E.E. and Zacharias, D.A. (2001) Physiol. Rev. 81, 21. 3.Talarico, E.F. et al. (2005) Mol. Vis. 11, 169. 4.Jensen, T.P. et al. (2007) J. Physiol. 579, 85. 5.Burette, A. and Weinberg, R.J. (2007) J. Comp. Neurol. 500, 1127. |
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