| 货号 | ACL-011-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Anoctamin-1 Channel |
| 反应种属 | R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Anoctamin (ANO, or TMEM16) is a family of membrane proteins which includes 10 members. This family is named so because these channels selective to ANions and have eight (OCT) transmembrane domains. Also, these channels are subject to glycosylation in their extracellular loops and have both intracellular N- and C-termini1. Members of this family are expressed in a broad range of different organisms ranging from mammals, flies, worms, plants as well as yeast1. Alternative splicing is known to affect these channels and regarding their oligomerization state, homedimerization has been observed although when heterologously expressed, these channels may hetero oligomerize2. Ano1 (or TMEM16A, DOG1 and others) the first member to be identified was found to be a Ca2+-activated Cl- channel3-5 therefore other members are likely to also be Cl- channels. These channels are expressed in many different tissues: bronchiolar epithelial cells, pancreatic acinar cells, proximal kidney tubule epithelium, retina, dorsal root ganglia and submandibular gland1. In fact, Ano1 gained a lot of attention as its activation may serve as a therapeutic treatment for cystic fibrosis since it is also expressed in the airways6. These Ca2+-activated Cl- channels are believed to play a role in development as knock out of Ano1 in mice causes abnormal development of the trachea7. Ano2 (TMEM16B) has been shown to mediate Ca2+-activated Cl- current in olfactory epithelium and photoreceptor synapses2,8,9. Although relatively newly discovered channels, they are being discovered in many medical indications. Ano1 has become a marker in gastrointestinal tumors as its expression is significantly upregulated in such tumors10,11. Similarly, Ano1 is also highly expressed other carcinomas12,13. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Hartzell, H.C.et al.(2009)J. Physiol.587.10,2127. 2.Sheridan, J.T.et al.(2011)J. Biol. Chem.286,1381. 3.Caputo, A.et al.(2008)Science322,590. 4.Yang, Y.D.et al.(2008)Nature455,1210. 5.Schroeder. B.C.et al.(2008)Cell134,1019. 6.Rock, J.R.et al.(2009)J. Biol. Chem.284,14875. 7.Rock, J.R.et al.(2008)Dev. Biol.321,141. 8.Stephan, A.B.et al.(2009)Proc. Natl. Acad. Sci. U.S.A.106,11776. 9.Hengl, T.et al.(2010)Proc. Natl. Acad. Sci. U.S.A.107,6052. 10.West, R.B.et al.(2004)Am. J. Pathol.165,107. 11.Espinosa, I.et al.(2008)Am. J. Surg. Pathol.32,210. 12.Huang, X.et al.(2006)Genes Chromosomes Cancer45,1058. 13.Carles, A.et al.(2006)Oncogene25,1821. |
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