| 货号 | ACC-322-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Mitochondrial Calcium Uptake Protein 1 |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Mitochondrial Ca2+ uptake was found to be mediated by the mitochondrial Ca2+ uniporter (MCU). MCU is a ruthenium‐red‐sensitive and highly selective Ca2+ ion channel that uptakes massive amount of Ca2+ across the inner membrane1. MICU1 is a ~54 kDa. protein with an amino‐terminal mitochondrial targeting sequence, a predicted transmembrane helix, and a cytosolic C‐terminus containing two classical EF‐hand Ca2+‐binding domains2. Mitochondrial calcium uptake 1 (MICU1) protein was identified as an essential element of mitochondrial Ca2+ uptake. MCU initially takes up Ca2+ very rapidly, but when [Ca2+] inevitably increases inside the matrix, MICU1 binds Ca2+ through its EF‐hand domains, exerting an inhibitory role on MCU‐dependent Ca2+entry3. RNA expression of MICU1 is strongly correlated across a variety of tissues including: stomach, kidney, small and large intestine, cerebral cortex, cerebellum, hypothalamus, spinal cord and skeletal muscles4. Loss-of-function mutations in MICU1 causes a brain and muscle disorder linked to primary alterations in mitochondrial Ca2+signaling5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Wang, L.et al.(2014) EMBO J.33,594. 2.Perocchi, F. et al.(2010)Nature467,291. 3.Collins, S. and Meyer, T.(2010)Nature467,283. 4.Plovanich, M.et al. (2013) PLoS ONE8,e55785. 5.Logan, C.V. et al. (2014) Nat. Genet. 46,188. |
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