| 货号 | ACC-321-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Mitochondrial Calcium Uniporter Regulator 1 |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Ca2+ flux across the mitochondrial inner membrane regulates bioenergetics, cytoplasmic Ca2+ signals and activation of cell death pathways1. Mitochondrial Ca2+ uptake occurs at regions of close apposition with intracellular Ca2+ release sites driven by the inner membrane voltage generated by oxidative phosphorylation and mediated by a Ca2+ selective ion channel called the uniporter2,3. Mitochondrial calcium uniporter (MCU) was recently identified as an ion-conducting pore4. MCUR1 (mitochondrial calcium uniporter regulator 1), belongs to the CCDC90 family, an integral membrane protein required for MCU-dependent mitochondrial Ca2+ uptake. MCUR1 binds to MCU and regulates ruthenium-red-sensitive MCU-dependent Ca2+uptake5. MCUR1 contains two transmembrane helices, where the N- and the short C-termini are exposed to the inter-membrane space5. MCUR1 is ubiquitously expressed in mammalian tissues including: skeletal muscle, brain, heart, lung, liver, kidney, large intenstine and spleen5. It was found that cells depleted of MCUR1 have abnormal bioenergetic properties similar to those observed in cells in which Ca2+ uptake is blocked. Thus, MCUR1 is necessary for MCU to efficiently promote mitochondrial Ca2+ uptake and to ensure normal mitochondrial bioenergetics5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Orrenius, S.et al. (2003) Nat. Rev. Mol. Cell Biol.4,552. 2.Csordas, G.et al.(2010)Mol. Cell39,121. 3.Santo-Domingo, J. and Demaurex, N.(2010)Biochim. Biophys. Acta1797,907. 4.Baughman, J.M.et al.(2011)Nature476,341. 5.Baughman, J.M.et al.(2011)Nature476,341. 6.Mallilankaraman, K.et al.(2012)Nat. Cell Biol.14,1336. |
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