| 货号 | ACC-314-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaV1.1 Channel |
| 反应种属 | H, M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated Ca2+channels (VGCCs) serve as key transducers coupling changes in cell surface membrane potential with local intracellular Ca2+ pathways. Among the three families of VGCCs, L-type Ca2+ channels (L-VGCCs), include four different isoforms of the α1 pore-forming subunit: CaV1.1,CaV1.2,CaV1.3 and CaV1.41. CaV1.1 (α1S) is the prototypical VGCCs. It was the first member of the CaV family to be cloned2. CaV1.1 is a single polypeptide composed of four relatively conserved repeats (I, II, II and IV) containing six α-helices a piece. The fourth α-helix of each repeat has a regularly spaced sequence of basic residues that is believed to be critical for voltage-sensing. The I–II-linker is the site of interaction with the intracellular β1asubunit3. CaV1.1 is expressed solely in skeletal muscle. It is localized in regions of the T-tubular membrane that are closely opposed to the sarcoplasmic reticulum (the TSR junction). The primary role of CaV1.1 is to serve as the voltage sensor for skeletal muscle-type excitation contraction (EC) coupling4. Mutations in CaV1.1 have been identified as causative for two congenital muscle pathophysiologies: hypokalemic periodic paralysis5 (HypoKPP) and malignant hyperthermia6. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Zuccotti, A.et al.(2011)Trends Pharmacol. Sci.32,366. 2.Tanabe, T.et al.(1987)Nature328,313. 3.Bannister, R.A. and Beam, K.G.(2013)Biochim. Biophys. Acta1828,1587. 4.Stroffekova, K.(2008)Pflugers Arch. 455,873. 5.Stroffekova, K.(2008)Pflugers Arch. 455,873. 6.Renner, D.R. and Ptacek, L.J.(2002)Adv. Neurol.88,235. 7.Jurkat-Rott, K. Lehmann-Horn, F.(2005)J. Clin. Invest.115,2000. |
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