| 货号 | ACC-233-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Pannexin 3 |
| 反应种属 | M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Pannexins are a class of membrane channels similar to the invertebrate Connexin family of gap channel proteins. There are currently three known types of Pannexin channels and the exact role of these channels is yet to be fully known1. A recent study suggests that despite similarity to the connexin family these channels are not gap-junctions or “hemichannels” as described in some publications but fully operational channels. These conclusions were derived because Pannexins, unlike gap-junctions, are found to be expressed and functional in single membranes facing the extra-cellular space and not as inter-cellular membranes in appositional cells. Pannexins are comprised of four transmembrane segments, two extra-cellular loops and both the amino and carboxi termini are facing the cytosol. Pannexins also have four conserved extracellular loop cysteines resulting in the possibility of two intra-pannexin disulfide bonds. Pannexin 3 has a glycosylation site at N254 and N71. Pannexin membrane channels are formed by 6-8 monomers and while Pannexin’s 3 exact oligomeric number has not been determined yet it is expected to be 6 with a greater similarity to Pannexin 1 than 2 2. There are two known subtypes of Panx3 in mice with different molecular weight and distribution. The first, weighing 43 kDa is mostly expressed in cartilage skin tissues and also in low levels in heart ventricle tissue. The second, weighing 70 kDa, and possibly functioning as a dimer is detected in lung, liver, thymus and spleen tissues3. Since full understanding of Pannexin 3 structure, expression and role in physiological and pathological tissues is yet to be obtained there is a definite need for further research. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Panchin, Y.et al.(2000)Curr. Biol.10,R473. 2.Sosinsky Gina, E.et al. (2011)Channels5,193. 3.Penuela, S.et al. (2007)J. Cell Sci.120,3772. |
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