| 货号 | ACC-113-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaVδ3 Subunit |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated Ca2+(CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. Based on their electrophysiological and pharmacological properties, Ca2+ channels have traditionally been classified into L, T, N, P/Q, and R types2. L-type calcium channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca2+ flow across the membrane, and the subunits α2δ, γ, and β3. The γ subunit is an integral membrane protein. The γ family consists of at least 8 members, which share a number of common structural features. Each member is predicted to possess four transmembrane domains, with intracellular N- and C-termini. The first extracellular loop contains a highly conserved N-glycosylation site and a pair of conserved cysteine residues5. CaVγ subunits inhibit CaV channel activity and modulate its activation and inactivation kinetics. CaVγ subunits have little effect on CaV channel trafficking4. CaVγ3 mRNAs are only detectable in mouse brain6. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Catterall, W.A.(2000)Annu. Rev. Cell. Dev. Biol.16,521. 2.Qin, N.et al.(2002)Mol. Pharmacol.62,485. 3.De Jongh, K.S.et al. (1990) J. Biol. Chem.265,14738. 4.Arikkath, J. et al. (2003)Curr. Opin. Neurobiol.13,298. 5.Lacinova, L.et al.(2005)Gen. Physiol. Biophys.Suppl.1,1. 6.Klugbauer N.et al.(2000)FEBS Lett.470,189. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |