| 货号 | ACC-103-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaVα2γ3 Subunit |
| 反应种属 | H, M, R |
| 应用 | IC, IH, LCI, WB |
| 供应商 | Alomone |
| 背景 | Voltage-gated Ca2+(CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. On the basis of their voltage activation properties, CaV channels can be further divided into two broad groups: the low (T-type) and high (L, N, P, Q and R-type) threshold-activated channels2. HVA channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca2+ flow across the membrane, and the auxiliary subunits α2δ, γ, and β3. The Ca2+ channel α2δ subunit is a heavily glycosylated protein that is encoded by a single gene and post-translationally cleaved to yield α2 and δ subunits linked by a disulfide bond with a single transmembrane segment4. The α2δ subunit regulates many functional aspects of Ca2+ channels, such as gating, regulating voltage dependent kinetics, and increasing functional channel density on the plasma membrane5. There are four proteins that comprise CaVα2δ:CaVα2δ1,CaVα2δ2, CaVα2δ3 and CaVα2δ46. The CaVα2δ3 subunit is predominantly expressed in neuronal tissue. The CaVα2δ3 subunit regulates all classes of HVA calcium channels. The Caα2δ3 subunits in the nerve terminal function in synaptic morphogenesis and cytoskeletal organization, and that this role is independent of their function in α1 subunit localization and physiology. CaVα2δ3 is likely to be the primary presynaptic α2δ isoform mediating morphological development of the neuromuscular junction (NMJ), since null alleles have such a large effect on NMJ development and abolish all action-potential evoked transmission7. Recent study shows that methylation-dependent transcriptional silencing of CaVα2δ3 may contribute to the metastatic phenotype of breast cancer8. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Catterall, W.A.(2000)Annu. Rev. Cell. Dev. Biol.16,521. 2.Qin, N.et al.(2002)Mol. Pharmacol.62, 485. 3.De Jongh, K.S.et al.(1990) J. Biol. Chem. 265,14738. 4.Sipos, I.et al.(2000)Pflug. Arch.439,691. 5.Dolphin, A.C.(2009)Curr. Opin. Neurobiol.19, 237. 6.Cooper C.L.et al.(1987)J. Biol. Chem.262,509. 7.Kurshan P.T.(2009)Nat. Neurosci.12,1415. 8.Palmieri, C.et al. (2012) Br. J. Cancer108, 375. |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |