| 货号 | ACC-067-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge.A Rabbit Polyclonal Antibody to SOCE-Associated Regulatory Factor |
| 反应种属 | H, M, R |
| 应用 | WB |
| 供应商 | Alomone |
| 背景 | SOCE-associated regulatory factor (SARAF) is a regulatory protein of cellular Ca2+ homeostasis, encoded by the TMEM66 gene. SARAF is an ER resident protein, which responds to cytosolic Ca2+ elevation after ER Ca2+ refilling. SARAF is highly conserved in vertebrates, and in mammals it is ubiquitously expressed with high transcript levels in the immune and neuronal tissues. SARAF structure contains validated signal peptide and a putative single membrane spanning domain, a serine-proline rich domain and arginine rich regions followed by a cluster of basic residues at its C-terminal tail1. Store-operated Ca2+ entry (SOCE) is an important Ca2+ influx pathway across plasma membrane in many non-excitable cells. In this pathway, intracellular Ca2+ release through IP3 receptor stimulated by a variety of agonists, results in reduction of Ca2+ concentration in the lumen of endoplasmic or sarcoplasmic reticulum. SARAF negatively regulates store operated calcium entry into cells and protects cells from calcium overfilling1,2. STIM, Ca2+ sensor, and Orai, the channel pore forming subunit proteins have been identified as the essential components enabling the reconstitution of Ca2+ release-activated Ca2+ channels that mediate SOCE. Knock-out of Orai1orSTIM1 in mice and mutations evoke SOCE in lymphocytes and other cells2,3. Several findings show that dysregulation of Ca2+ homeostasis is associated with a plethora of pathological conditions including neurodegenerative diseases, skeletal, muscular and cardiovascular disorders2. Inherited defects in SOCE due to mutations in genes of the Ca2+ release-activated Ca2+ (CRAC) channel complex causes patients to suffer from a severe form of immunodeficiency that is due to defects in the function of T cells, NK cells and potentially other immune cells3. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Palty, R.et al. (2012) Cell 149,425. 2.Pan, Z.et al.(2014)BMB Rep.47,69. 3.Feske, S. (2011) Ann. N Y Acad. Sci. 1238,74. |
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