| 货号 | ACC-064-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to STIM2 |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Cytosolic Ca2+ has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The mechanism controlling the influx of intracellular Ca2+ either by calcium-release-activated Ca2+ channels (CRAC) or from intracellular stores has lately become the focus of intense research. Recently, several key players of the store-operated complex have been identified: the Orai family consists of three members: Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2.3 Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum (ER) Ca2+ sensor.3,4 WhileSTIM1 appears to be localized intracellularly at the ER membrane and at a much lower extent on the cell surface of several cell types, STIM2 appears to be localized solely at the ER membrane.5 The function of STIM2 still remains elusive and several models have been suggested.6-8 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Eisner, D.A.et al.(2005)Exp. Physiol.90,3. 2.Chakrabarti, R. and Chakrabarti, R.(2006)J. Cell. Biochem.99,1503. 3.Feske, S.et al.(2006)Nature441,179. 4. Pickett, J. (2006) Nat. Rev. Mol. Cell Biol.7,794. 5.Dziadek, M.A. and Johnstone, L.S.(2007)Cell Calcium42,123. 6.Parvez, S.et al.(2007)FASEB J. 22,752. 7.Brandman, O.et al.(2007)Cell131,1327. 8.Soboloff, J.et al.(2006)Curr. Biol.16,1465. |
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