| 货号 | ACC-047-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPM7 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the six TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC (canonical), TRPV (vanilloid) and TRPM (melastatin). To date, three extra subfamilies are also considered to belong to the TRP family; the TRPA, TRPML, and the TRPP.1-4 The TRPM subfamily consists of eight members, TRPM1 to TRPM8, which also can be further subdivided into four subgroups based on their sequence homology: (1)TRPM1 and TRPM3 (2) TRPM6 and TRPM7 (3) TRPM4 and TRPM5 (4) TRPM2 and TRPM8.5 TRPM7 and TRPM6 are involved in Mg2+ homeostasis and are unique among the TRP family members, possessing a functional kinase domain at their C-terminus.6,7 Although the kinase is not necessary to the function of the channel it may have a role in modulating the activation of the channel.7 Recent work demonstrated that TRPM7 is a critical mediator of anoxic cell death.7,8 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Montell, C.et al. (2002)Mol. Cell.9,229. 2.Clapham, D.E.(2003)Nature426,517. 3.Moran, M.M.et al. (2004) Curr. Opin. Neurobiol.14,362. 4.Clapham, D.E.et al.(2003)Pharmacol. Rev.55,591. 5.Harteneck, C.(2005)Naunyn. Schmiedebergs. Arch. Pharmacol.371,307. 6.Schmitz, C.et al.(2005)J. Biol. Chem.280,37763. 7.Aarts, M.M.et al. (2005) Neuroscientist11,116. 8.Aarts, M.M.et al.(2005)Pflugers. Arch. 451,243. |
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