| 货号 | ACC-039-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPV2 Channel |
| 反应种属 | M, R |
| 应用 | IC, IFC, IH, IP, LCI, WB |
| 供应商 | Alomone |
| 背景 | TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 The TRP channels have putative six-transmembrane domains (TM) with a pore domain between the fifth and the sixth TM, and all assemble as tetramers. Both the N- and the C-terminus of all TRPs are intracellular.3 According to IUPHAR, the TRP family is comprised of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three additional subfamilies are also considered to belong to the TRP family: the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5 Four members of the TRPV family have been described as a thermosensitive ion channels (TRPV1 to TRPV4). Each channel exhibits distinct thermal activation thresholds ranging from noxious cold (<17°C) to noxious heat (>52°C).6,7 Although it shares around 50% homology with TRPV1, TRPV2 is not activated by capsaicin nor by protons. It has a high temperature threshold of ~52°C and is considered to play an essential role in the perception of high-intensity noxious heat stimulation.8-10 The TRPV2 is also considered to be a stretch-activated channel and to play a role in skeletal and cardiac muscle degeneration and pain pathway.8 TRPV2 channel is expressed in DRG neurons, different brain region and non-neuronal tissues such as spleen, lung and, intestine and in component of the immune system.5,11-12 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Montell, C. et al. (2002) Mol. Cell. 9, 229. 2.Clapham, D.E. (2003) Nature 426, 517 3.Moran, M.M. et al. (2004) Curr.Opin.Neurobiol. 14, 362. 4.Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591. 5.Gunthorpe, M.J.et al. (2002) Trends. Pharmacol. Sci. 23, 183. 6.Tominaga, M. and Caterina, M.J. et al. (2004) J. Neurobiol. 61, 3. 7.Voets, T. et al. (2004) Nature 430, 748. 8.Pedersen, S.F. et al. (2005) Cell Calcium 38, 233. 9.Muraki, K. et al. (2003) Circ. Res. 93, 829. 10.Shimosato, G. et al. (2005) Pain 119, 225. 11.Saunders, C.I. et al. (2007) Mol. Immunol. 44, 1429. 12.Caterina, M.J. et al. (1999) Nature 398, 436. |
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