| 货号 | ACC-037-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPA1 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, LCI, WB |
| 供应商 | Alomone |
| 背景 | The TRPA family is comprised of only one mammalian member, the TRPA1 (formerly named ANKTM1). TRPA1 is expressed in peripheral sensory neurons, where it is suggested to contribute to the detection of painful stimuli.1 Originally it was thought that TRPA channels sensed painfully cold temperatures2, but a more conservative description is that TRPA1 is sensitive to membrane/cytoskeletal perturbations by cold3-5 and perhaps stretch.6 In addition, it is sensitive to pungent natural compounds present in cinnamon oil, mustard oil, and wintergreen oil. TRPA1 is also expressed in hair cells, where its role in sensing mechanical forces is still unclear and controversial.1 TRPA1 has similar structure as all TRP ion channel members, six transmembrane domains, intracellular N-and C-terminus. However, its N-terminus domain possesses 17 ankyrin repeats that might indicate its potential role as a mechanosensor.6,7 TRPA1 is expressed in nociceptive neurons expressing TRPV1 as well and might serve as a marker for poly-modal nociceptors.8 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Hill, K. and Schaefer, M. (2007)J. Biol. Chem.282,7145 2.Story, G.M.et al. (2003) Cell112,819. 3.Bandell, M.et al.(2004)Neuron41,849. 4.Jordt, S.E.et al.(2004)Nature427,260. 5.Zurborg, S. et al.(2007)Nat. Neurosci.10,277. 6.Corey, D.P.et al.(2004)Nature432,723. 7.Sotomayor, M.et al.(2005)Structure13,669. 8.Clapham, D.E.(2002)Science295,2228. |
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