| 货号 | ACC-029-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to Rat TRPV1 Channel |
| 反应种属 | R |
| 应用 | IC, IH, LCI, WB |
| 供应商 | Alomone |
| 背景 | TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5 TRPV1 channel has many activators among them heat, protons, vanilloids like capsaicin, reiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.6,7 TRPV1 is expressed predominantly in nociceptors and in sensory neurons. Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Montell, C. et al. (2002) Mol. Cell. 9, 229. 2.Clapham, D.E. (2003) Nature 426, 517. 3.Moran, M.M. et al. (2004) Curr. Opin. Neurobiol. 14, 362. 4.Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591. 5.Gunthorpe, M.J. et al. (2002) Trends. Pharmacol. Sci.23,183. 6.Ross, R.A.et al.(2003)Br. J. Pharmacol. 140,790. 7.Tominaga, M.et al.(1998)Neuron. 21,531. 8.Agopyan, N.et al.(2004)Am. J. Physiol .Lung .Cell .Mol. Physiol.286,L563. 9.Reilly, C.A.et al.(2003)Toxicol. Sci. 73,170. |
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