| 货号 | ACC-021-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaV3.1 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage-dependent Ca2+ channels provide a pathway for rapid influx of Ca2+ into cells, which plays a crucial role in both electrical and metabolic signaling.1 T-type currents are transduced via channel proteins encoded by three genes that compose a subfamily within the Cav channel family.2-3 The activity of T-type channels contributes to several known physiological and pathophysiological phenomena including burst firing in neurons, pace making activity in the heart and secretion from endocrine tissues.2 There are three cloned T-type channel isoforms. CaV3.1 (α1G) and CaV3.2 (α1H) are widely distributed whereas the expression of CaV3.3 (α1I) is restricted to the central nervous system.2 CaV3.1 and CaV3.2 are also expressed in the kidney, but little is known about their physiological role there. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Serrano, J.R.et al. (1999)J. Gen. Physiol.114,185. 2.Perez-Reyes, E. (2003) Physiol. Rev.83,117. 3.Wain, H.M.et al. (2002)Nucleic Acids Researc30,169. 4.Andreasen, D.et al. (2000)Am.J.Physiol.279,F997. |
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