| 货号 | ACC-017-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to TRPC6 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IFC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals, about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC(canonical),TRPV(vanilloid),TRPM(melastatin),TRPML(mucolipins),TRPP (polycystin) and the TRPA (ANKTM1) ion channels.1-4 The TRPC subfamily consists of seven proteins named TRPC1 to 7 which can be further divided into four subgroups based on their sequence homology and functional similarities: 1.TRPC1. 2.TRPC4andTRPC5. 3.TRPC3, TRPC6, TRPC7. 4.TRPC2.2,5 They are highly expressed in the central nervous system and to a lesser extent in peripheral tissues. TRPC6 can form heterotetramers with TRPC3 and TRPC7. It is primarily expressed in brain, lung and muscle. High levels of expression of the channel were also found in human platelets. Recently it was reported that TRPC6 is also expressed in the kidney where a mutated channel has been implicated in kidney failure disease.6,7 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Moran, M.M.et al. (2004) Current Opin. Neurobiol.14, 362. 2.Clapham, D.E.et al. (2003) Pharmacol. Rev.55, 591. 3.Clapham, D.E.(2003)Nature426, 517. 4.Padinjat, R. and Andrews, S. (2004) J. Cell. Sci.117, 5707. 5.Huang, C.L. (2004) J. Am. Soc. Nephrol.15, 1690. 6.Winn. M.P.et al. (2005) Science,308, 1801. 7.Reiser, J.et al. (2005) Nat. Genet.37, 739. |
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