| 货号 | ACC-005-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaV1.3 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous.1,2 The CaV1.3 channels are also expressed, as are other L-type channels, in neurons and neuroendocrine cells. However, accumulated data has shown the expression of CaV1.3 in heart and suggests that it plays a major role in the generation of cardiac pacemaker activity.3,4 Several peptidyl toxins have been described that are specific L-type channel blockers. These include the Mamba toxins Calcicludine(#C-650),Calciseptine(#C-500) andFS-2(#F-700). So far no selective blocker for one of the CaV1 isoforms has been described. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized peptide. |
| 参考文献 | 1.Catterall, W.A.et al.(2003)Pharmacol. Rev.55,579. 2.IUPHAR 3.Mangoni, M.E.et al(2003)Proc. Natl. Acad. Sci.100,5543. 4.Zhang, Z.et al.(2005)Circulation112,1936. |
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