| 货号 | ACC-002-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaV2.2 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, IP, WB |
| 供应商 | Alomone |
| 背景 | Voltage dependent Ca2+ channels (CaV channels) are pivotal players in many physiological roles such as secretion, contraction, migration and excitation.1 The voltage dependent Ca2+ channels are composed of several subunits; α1, β, α2δ and γ. CaV channels were originally divided into six physiological types: L, N, P, Q, R, and T type. The CaV2.2 (formally named α1B) composes the α1 poreforming subunit for the N type Ca2+ channel family. They are involved in neurotransmitter release from central neurons, including glutamate, γ-aminobutyric acid, acetylcholine, dopamine and noradrenaline.2 The CaV2.2 is expressed preferentially in the central nervous system, where along with CaV2.1, it is responsible for pre-synaptic Ca2+ influx and neurotransmitter release.1,3 The CaV2.2 channel is negatively regulated by many different GPCRs. There are two ways that this is done: either by directly binding Gβγ to the channel or by an indirect mechanism involving second messenger and channel phosphorylation.4 ω-Conotoxin GVIA (#C-300) is a specific blocker of Cav2.2 Ca2+ channels. It specifically blocks N-type Cav channels by binding to the Cav2.2 α1 subunit (α1B) and its action is only partially reversible.5,6 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Tsunemi, T.et al.(2002)J. Biol. Chem.277,7214. 2.Beuckmann, C.T.et al. (2003) J. Neurosci.23,6793. 3.Scheuber, A.et al.(2004) J. Neurosci.24,10402. 4.Dascal, N. (2001) Trends Endocrinol. Metab. 12, 391. 5.McCleskey, E. W.et al.(1987)Proc. Natl. Acad.Sci. USA84, 4327. 6.Feng, Z. P.et al.(2001)J. Biol. Chem. 276,15728. |
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