| 货号 | ACC-001-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to CaV2.1 Channel |
| 反应种属 | H, M, R |
| 应用 | IC, IH, WB |
| 供应商 | Alomone |
| 背景 | Voltage dependent Ca2+ channels (Cav channels) are pivotal players in many physiological roles such as secretion, contraction migration and excitation.1 The voltage dependent calcium channels are composed of several subunits; α1, β, α2δ and γ. Cav channels were originally divided into six physiological types: L, N , P, Q, R, and T type. The Cav2.1 (formally named α1A) makes up the α1 poreforming subunit in P/Q type Ca2+ channel family. It is expressed preferentially in the central nervous system where along with Cav2.2 is responsible for pre-synaptic Ca2+ influx and neurotransmitter release.1,2 Mutations in the Cav2.1 have been shown to cause several neurological disorders among them are familial hemiplegic migraine, episodic ataxia type 2, and spinocerebellar ataxia type 6 (SCA6).1,3-5 The involvement of Cav2.1 in synaptic transmission was assessed by using ω-Agatoxin IVA (#RTA-500), a specific blocker of the Cav2.1 channel.6 The blocking sensitivity is dependent on the a subunit isoform and on the splice variant.7,8 |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Tsunemi, T.et al.(2002)J. Biol. Chem.277,7214. 2.Scheuber, A.et al.(2004) J. Neurosci.24,10402. 3.Ophoff, R. A.et al(1996)Cell 87,543. 4.Ishikawa, K.et al.(1997)Am. J. Hum. Genet. 61,336. 5.Tottene, A.et al.(2002)Proc. Natl. Acad. Sci. U.S.A. 99,13284. 6.Mintz, I.M.et al. (1992) Nature355,827. 7.Moreno, H.et al.(1997)Proc. Natl. Acad. Sci. U.S.A. 94,14042. 8.Bourinet, E.et al. (1999) Nat. Neurosci.2,407. |
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