| 货号 | AAR-023-25ul |
| 描述 | Each antibody ordered from Alomone Labs is supplied with its corresponding control peptide (antigen), free of charge. A Rabbit Polyclonal Antibody to β1-Adrenoceptor |
| 反应种属 | M, R |
| 应用 | IH, WB |
| 供应商 | Alomone |
| 背景 | β-Adrenergic receptor (βAR) belongs to the superfamily of G protein-coupled receptors (GPCRs). β-Adrenergic receptor (βAR) stimulation by the sympathetic nervous system or circulating catecholamines is involved in peripheral blood circulation, metabolic regulation, muscle contraction, and central neural activities. In the heart, acute βAR stimulation serves as the most powerful means to regulate cardiac output in response to a fight-or-flight situation. There are three βAR subtypes, β1AR, β2ARandβ3AR in cardiac myocytes1. The receptors consist of seven membrane-spanning domains, three intra- and three extracellular loops, one extracellular N-terminal domain, and one intracellular C-terminal tail2. β1AR is the predominant receptor subtype expressed in human cardiomyocytes. β1AR is also expressed in the kidney3. It has been implicated in adipogenesis and memory formation4. β1AR has been widely connected with heart disease. Both the downregulation and overstimulation of β1AR have been connected to myocyte apoptosis. In addition chronic heart failure is characterized by abnormalities in β1AR signal transduction. It was demonstrated that heart failure is also inducible in animal models by overexpression of components of the β1AR signal transduction cascade. Transgenic mice overexpressing β1AR develop, with aging, heart failure similar to that observed in dilated cardiomyopathy in humans5. |
| 运输条件 | Ambient |
| 存放说明 | -20 |
| 纯度 | Affinity purified on immobilized antigen. |
| 参考文献 | 1.Gilbert, C.E.et al.(2014)Int. J. Mol. Sci.15,2929. 2.Woo, A.Y.et al. (2012) Acta Pharmacol. Sin.33,335. 3.Vicco, M.H.et al.(2014)Can. J. Cardio.30,332. 4.Wallukat, G.et al.(2002) Herz 27,683. 5.Kamal, F.A.et al.(2014)Circ. Res.114,742. |
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