Mouse Lymphotoxin beta R/TNFRSF3 Affinity Purified PAb (100 UG)【科瑞奥博】

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Mouse Lymphotoxin beta R/TNFRSF3 Affinity Purified PAb (100 UG)

货号： AF1008 基本售价：询价规格： -

产品信息

概述
货号	AF1008
别名	CD18; D12S370; ltbetar; LT-BETA-R; LTBR; lymphotoxin B receptor; lymphotoxin beta receptor (TNFR superfamily, member 3); Lymphotoxin-beta receptor; TNF RIII; TNF Rrp; TNFCRTNF-RIII; TNFR superfamily, member 3; TNFR2-RP; TNFR3; TNF-R-III; TNFR-RP; TNFRSF3; TNFRSF3TNFR-III; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; tumor necrosis factor receptor superfamily member 3; tumor necrosis factor receptor superfamily, member 3; Tumor necrosis factor receptor type III
全称	Lymphotoxin beta Receptor
反应种属	Mouse
应用	Western Blot(0.1 µg/mL) Flow Cytometry(2.5 µg/10⁶cells) Immunohistochemistry(5-15 µg/mL)
目标/特异性	Detects mouse Lymphotoxin beta R/TNFRSF3 in direct ELISA and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant human (rh) LT beta R is observed, and less than 1% cross-reactivity with recombinant mouse (rm) 4-1BB, rmCD27, rmOPG, rmRANK, rmCD30, rmCD40, rhDR6, rmTNF RI, rmTNF RII, rmEDAR, rmFas and rmGITR is observed.
使用方法	Western Blot: 0.1 µg/mL Flow Cytometry: 0.25 µg/10⁶cells Immunohistochemistry: 5-15 µg/mL
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分
是否允许进口	否
是否危险品	是

性能
供应商	R&D Systems
Entrez Gene IDs	4055 (Human); 17000 (Mouse); 297604 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. A dendritic-cell-stromal axis maintains immune responses in lymph nodes. Authors: Kumar V, Dasoveanu D, Chyou S, Tzeng T, Rozo C, Liang Y, Stohl W, Fu Y, Ruddle N, Lu T Immunity, 2015;42(4):719-30. Species: Mouse Sample Type: Whole Cells Application: Neut TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. Authors: Baluk P, Yao LC, Feng J, Romano T, Jung SS, Schreiter JL, Yan L, Shealy DJ, McDonald DM J. Clin. Invest., 2009;119(10):2954-64. Species: Mouse Sample Type: Whole Tissue Application: IHC Frozen CXCL13 production by an established lymph node stromal cell line via lymphotoxin-beta receptor engagement involves the cooperation of multiple signaling pathways. Authors: Suto H, Katakai T, Sugai M, Kinashi T, Shimizu A Int. Immunol., 2009;21(4):467-76. Species: Mouse Sample Type: Whole Cells Application: Neut Organizer-like reticular stromal cell layer common to adult secondary lymphoid organs. Authors: Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Suematsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A J. Immunol., 2008;181(9):6189-200. Species: Mouse Sample Type: Whole Cells Application: Bioassay Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. Authors: Katakai T, Hara T, Sugai M, Gonda H, Shimizu A J. Exp. Med., 2004;200(6):783-95. Species: Mouse Sample Type: Whole Cells Application: Flow
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant mouse Lymphotoxin beta R/TNFRSF3 Ser28-Pro218 Accession # P50284
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	Lymphotoxin beta receptor (LTbR), also known as TNFRSF3, TNF RIII, and TNF Rrp, is a transmembrane receptor for the homotrimeric LIGHT/TNFSF14 and the heterotrimeric LTalpha1/beta2. LTbR engagement induces production of IL-7, RANK, TRANCE/RANK L, VEGF-C, the adhesion molecules VCAM-1, ICAM-1, and MAdCAM, and the chemokines CXCL13, CCL19 and CCL21. LTbR is expressed on mesenchymal stromal organizing cells that give rise to stroma of primary (thymus), secondary (tonsils, lymph nodes, and Peyers patches) and tertiary (ectopic inflammatory) lymphoid structures. It is expressed by hepatocytes and is upregulated in regeneration, hepatitis, and hepatocellular carcinoma where it regulates lipid metabolismd. A soluble form of LTbR can be released and functions an inhibitor of transmembrane LTbR.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Cytokines and Receptors in Allergy and Asthma Regulation of Apoptosis by TNF Superfamily Members TNF Superfamily TNF Superfamily Receptors

参考图片

Detection of Lymphotoxin beta R/TNFRSF3 in NIH‑3T3 Mouse Cell Line by Flow Cytometry. NIH‑3T3 mouse embryonic fibroblast cell line was stained with Goat Anti-Mouse Lymphotoxin beta R/TNFRSF3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1008, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107). View our protocol for Staining Membrane-associated Proteins.