| 货号 | BAF628 |
| 别名 | chemokine (C-C motif) ligand 15; Chemokine CC-2; HCC-2; HCC-2Lkn-1; Leukotactin 1; Leukotactin-1; LKN1; LKN-1; Macrophage inflammatory protein 5; MIP-1 delta; MIP5; MIP-5; MIP-5MIP-1d; Mrp-2b; NCC-3; NCC-3MIP-1D; NCC3MRP-2B; new CC chemokine 3; SCYA15member 15; Small-inducible cytokine A15 |
| 反应种属 | Human |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects human CCL15/MIP-1δ in Western blots. In this format, this antibody shows a preference for the 68 amino acid (aa) residue isoform over the 92 aa isoform of human CCL15/MIP-1δ and less than 1% cross-reactivity with rh6Ckine, rhBLC/BCA-1, rhENA-78, rhEotaxin, rhEotaxin-2, rhFractalkine, rhGCP‑2, rhGRO alpha, rhGRO beta, rhGRO gamma, rhHCC‑1, rhHCC‑4, rhI-309, rhIL-8, rhMCP‑1, rhMCP-2, rhMCP‑3, rhMCP‑4, rhMDC, rhMIG, rhMIP‑1 alpha, rhMIP‑1 beta, rhMIP‑3 alpha, rhMIP-3 beta, rhMPIF‑1, rhNAP‑2, rhPARC, rhRANTES, rhSDF‑1 alpha, rhSDF‑1 beta, rhTarc, rhTECK, and rhVIC is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 6359 (Human) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | E. coli-derived recombinant human CCL15/MIP-1δ (R&D Systems, Catalog #628-LK) Ser46-Ile113 Accession # Q16663 |
| 生物活性 | Human |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | CCL15, also named Leukotactin-1 (LKN-1), MIP-5, HCC-2, and NCC-3, is a novel human CC chemokine whose gene was mapped to human chromosome 17 adjacent to the HCC-1 gene. CCL15/LKN-1, together with mouse C10, mouse MIP-1 gamma and human MPIF-1, constitute a subgroup of CC chemokines which contain six instead of four conserved cysteine residues. The two additional cysteine residues in CCL15/LKN-1 have been shown to form a third disulfide bond CCL15/LKN-1 cDNA encodes a 113 amino acid (aa) residue precursor protein with a putative signal peptide of 21 aa residues that is cleaved to generate a 92 aa residue mature protein. In recombinant CCL15/LKN-1 preparations produced in insect cells and in yeast, amino-terminal truncations were found to have occurred. The major forms of CCL15/LKN-1 secreted by insect cells and yeast were reported to be proteins of 68 and 66 aa residues, respectively. The full length and the amino-terminal truncated forms of human CCL15δ/LKN-1 have been shown to be potent chemoattractants for monocytes and T-lymphocytes. These proteins can also chemoattract eosinophils and have been shown to induce calcium flux in human CCR1 transfected cells. Additionally, CCL15/LKN-1 can suppress colony formation by human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinations of growth factors. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
|