Human IL-13 R alpha 1 Biotinylated Affinity Purified PAb (50 UG)【科瑞奥博】

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Human IL-13 R alpha 1 Biotinylated Affinity Purified PAb (50 UG)

货号： BAF152 基本售价： 5958.6 元规格： -

产品信息

概述
货号	BAF152
描述	For ELISA the Antibody Pairs information：Capture antibody：MAB146；Detection antibody：BAF152; and protein: 146-IR-100
别名	bB128O4.2.1 (interleukin 13 receptor, alpha 1); Cancer/testis antigen 19; CD213a1 antigen; CD213a1; CT19; IL13 receptor alpha-1 chain; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL13R; IL13RA; IL-13Ra; IL13RA1; IL-13RA1; IL-13R-alpha-1; interleukin 13 receptor, alpha 1; interleukin-13 receptor subunit alpha-1; NR4
全称	Interleukin 13 Receptor alpha 1
反应种属	Human
应用	Western Blot,Flow Cytometry,ELISA Capture (Matched Antibody Pair),ELISA Detection (Matched Antibody Pair),ELISA Standard
目标/特异性	Detects human IL-13 R alpha 1 in ELISAs and Western blots. In sandwich ELISAs, less than 1% cross-reactivity with recombinant human (rh) IL‑13 R alpha 2, recombinant mouse (rm) IL-13 R alpha, rhIL-4 R, rhIL-5 R alpha, and rhIL-9 R is observed.
使用方法	Western Blot: 0.1 µg/mL Flow Cytometry: 2.5 µg/10⁶cells ELISA Capture (Matched Antibody Pair): 2-8 µg/mL ELISA Detection (Matched Antibody Pair): 0.1-0.4 µg/mL ELISA Standard :
来源	Reconstitute at 0.2 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3597 (Human); 16164 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. Authors: Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, Stingl G, Rot A, Maurer D J. Immunol., 2004;173(11):6592-602. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Antigen Affinity-purified
免疫原	Mouse myeloma cell line NS0-derived recombinant human IL‑13 R alpha 1 Ala27-Thr343 (Thr130Ile) Accession # Q5JSL4
生物活性	Human
标记	Biotin
溶解方法	Reconstitute at 0.2 mg/mL in sterile PBS.
背景	Two type 1 membrane proteins belonging to the hemopoietin receptor family have been cloned and shown to bind IL-13 with differing affinities. The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha or NR4, is now referred to as IL-13 R alpha 1. The high-affinity IL-13 binding protein, previously also designated IL-13 R or IL-13 R alpha , is now referred to as IL-13 R alpha 2. The human IL-13 R alpha 1 was originally cloned based on sequence homology to the mouse IL-13 R alpha 1. The IL-13 R alpha 1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region, and a 59 aa residue cytoplasmic tail. Human and mouse IL-13 R alpha 1 share 76% aa sequence identity. The extracellular domain of IL-13 R alpha 1 is also closely related to that of IL‑13 R alpha 2. IL‑13 R alpha 1 has been shown to combine with the IL-4 R alpha to form a high-affinity receptor complex capable of transducing an IL-13-dependent proliferative signal. The role of IL-13 R alpha 2 in IL-13 signaling remains to be elucidated.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Caput, D.et al. (1996) J. Biol. Chem. 271:16921. Donaldson, D.D.et al. (1998) J. Immunol. 161:2317. Aman, M.J.et al. (1996) J. Biol. Chem. 271:29265. Hilton, D.J.et al. (1996) Proc. Natl. Acad. Sci. USA 93:497. Zhang, J.G.et al. (1997) J. Biol. Chem. 272:9474.

参考图片

Detection of IL‑13 R alpha 1 in Human Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Human IL‑13 R alpha 1 Biotinylated Antigen Affinity‑purified Polyclonal Antibody (Catalog # BAF152, filled histogram) or control antibody (Catalog # BAF108, open histogram), followed by Streptavidin-Phycoerythrin (Catalog # F0040).