| 货号 | AB924 |
| 别名 | EC 3.4.24; EC 3.4.24.-; EC 3.4.24.80; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24 (membrane-inserted); matrix metalloproteinase-24; membrane-type 5 matrix metalloproteinase; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP-24; MT5MMP; MT5-MMP; MT5-MMPMMP25; MT-MMP 5; MTMMP5; MT-MMP5 | 全称 | Matrix Metalloproteinase 24/Membrane Type 5 MMP |
| 反应种属 | Human/Mouse |
| 应用 | Western Blot(1 µg/mL) Immunohistochemistry(5-15 µg/mL) Immunoprecipitation(25 µg/mL) |
| 目标/特异性 | Detects human and mouse MMP‑24/MT5-MMP in Western blots. |
| 使用方法 | Western Blot: 1 µg/mL Immunohistochemistry: 5-15 µg/mL Immunoprecipitation: 25 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 10893 (Human); 17391 (Mouse) |
| 纯化方式 | Protein A or G purified |
| 免疫原 | E. coli-derived recombinant human MMP‑24/MT5-MMP |
| 生物活性 | Human, Mouse |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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MMP‑24 in Human Brain. MMP‑24 was detected in immersion fixed paraffin-embedded sections of human brain using Rabbit Anti-Human/Mouse MMP-24/MT5-MMP Polyclonal Antibody (Catalog # AB924) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rabbit HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS006) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of neurons. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. | |
MMP‑24 in Human Astrocytoma. MMP‑24 was detected in immersion fixed paraffin-embedded sections of human brain (astrocytoma) using Rabbit Anti-Human/Mouse MMP‑24/ MT5-MMP Polyclonal Antibody (Catalog # AB924) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rabbit HRP-AEC Cell & Tissue Staining Kit (red; Catalog # CTS006) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of cancer cells. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections. |
