| 货号 | BAF5187 |
| 别名 | arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor | 全称 | Conserved Dopamine Neurotrophic Factor |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse CDNF in Western blots. In Western blots, approximately 30% cross-reactivity with recombinant human CDNF is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 441549 (Human); 227526 (Mouse); 361276 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse CDNF Leu27-Leu187 Accession # Q8CC36 |
| 生物活性 | Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | CDNF (conserved dopamine neurotrophic factor), also called Armetl1 (arginine-rich, mutated in early stage tumors-like 1) in mouse, is a secreted protein that shares 62% amino acid identity with human MANF (mesencephalic-astrocyte-derived neurotrophic factor), also called Armet in mouse. Like MANF and GDNF (glial cell-derived neurotrophic factor), CDNF promotes survival of dopaminergic neurons in vitro. In a rat Parkinsons disease model, CDNF also promotes rescue and restoration of dopaminergic neurons in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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