| 货号 | BAF4885 |
| 别名 | Anticoagulant protein C; APC; Autoprothrombin IIA; Blood coagulation factor XIV; EC 3.4.21; EC 3.4.21.69; PC; PROC; PROC1; protein C (inactivator of coagulation factors Va and VIIIa); Protein C; vitamin K-dependent protein C | 全称 | Vitamin K-dependent Protein C |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse Coagulation Factor XIV/Protein C in Western blots. In Western blots, approximately 15% cross-reactivity with recombinant human Coagulation Factor XIV/Protein C is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5624 (Human); 19123 (Mouse); 25268 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Chinese hamster ovary cell line CHO-derived recombinant mouse Coagulation Factor XIV/Protein C Ile19-Leu460 Accession # P33587 |
| 生物活性 | Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Coagulation Factor XIV / Protein C is a vitamin K-dependent serine protease synthesized in liver as a single-chain precursor. Present in plasma at 3 to 5 mg/L, protein C plays a key role in anticoagulation. Physiologically, the inactive forms of protein C are converted to the active form by thrombin, which releases the activation peptide. The active protein C cleaves factor VIIIa and Va to inactivate them. This anticoagulation activity can be enhanced by a presence of a cofactor such as protein S. In hereditary thrombophilia, Coagulation Factor XIV /protein C deficiency is caused by a genetic mutation which affect protein C activity. A severe recessive form may result in massive thrombosis fatal to the patient. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
|