| 货号 | BAF3179 |
| 别名 | amyloid beta (A4) precursor-like protein 1; amyloid precursor-like protein 1; amyloid-like protein 1; APLPAPLP-1 | 全称 | Amyloid-like Protein 1 |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse APLP-1 in Western blots. In Western blots, approximately 45% cross-reactivity with recombinant human APLP-1 is observed and less than 1% cross-reactivity with recombinant mouse APLP-2 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 1803 (Human); 333 (Human); 502317 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse APLP-1 Gly37-Arg582 Accession # Q03157 |
| 生物活性 | Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | Amyloid Precursor-like Proteins are members of the amyloid precursor protein (APP) superfamily of transmembrane proteins. APLPs show the same structural organization as APP, except APP contains a short Ab sequence associated with Alzheimer’s disease. All family members are proteolytically processed and appear to play a role in neurite outgrowth and copper metabolism. APLPs are proteolytically cleaved by MMPs and secretases, and form both homodimers and heterodimers with APP and other APLPs. APLP-1 is expressed post-synaptically in cortical neurons. It functions as an adhesion protein through interactions with heparin and collagen I. APLP-1 can be cleaved by gamma-Secretase or Caspases to release intracellular fragments that activate transcription or enhance apoptosis, respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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