Mouse HVEM/TNFRSF14 Biotinylated Affinity Purified PAb (50 UG)
货号：
BAF2516 基本售价：
5532.3 元 规格：
-
产品信息
概述| 货号 | BAF2516 |
| 别名 | ATAR; CD270 antigen; CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HveA; HVEMTR2HVEAATAR; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entrymediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2 |
全称 | Herpesvirus Entry Mediator | | 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL)
|
| 目标/特异性 | Detects mouse HVEM in Western blots. In Western blots, less than 5% cross-reactivity with recombinant human (rh) HVEM is observed and less than 2% cross-reactivity with recombinant mouse (rm) DR3, rmFas, rmGITR, rmTWEAK R, rm4-1BB, rmBAFF R, rmCD27, rmCD30, rmCD40, rmEDAR, rmNGF R, rmOX40, rmRANK, rmTNF RI, rmTNF RII, rhDR6, rhTRAIL R3, and rhTRAIL R4 is observed. |
| 使用方法 | Western Blot: 0.1 µg/mL
|
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 8764 (Human); 230979 (Mouse); 102137807 (Cynomolgus Monkey) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse HVEM
Extracellular domain |
| 生物活性 | Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | HVEM/TNFRSF14 (herpesvirus entry mediator) is a transmembrane protein that is most highly expressed on naïve, memory, and regulatory T cells but declines during T cell activation. It is present at low levels on most resting leukocytes. HVEM is a receptor for BTLA, CD160, and LIGHT. A cis interaction between HVEM and BTLA promotes cell survival, while trans interaction promotes a state of lymphocyte inactivity. LIGHT is expressed following T cell activation and competes with BTLA for HVEM binding, leading to a proinflammatory response. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding. Human, but not mouse, HVEM can also bind lymphotoxin-alpha. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - B Cell Development and Differentiation
- Co-stimulatory and Co-inhibitory Molecules
- Monocyte Markers
- Regulation of Apoptosis by TNF Superfamily Members
- Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
- Regulation of T Cell Co-stimulation by TNF Superfamily Members
- TNF Superfamily
- TNF Superfamily Receptors
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