| 货号 | BAF1994 |
| 别名 | bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; EC 1.14.11; EC 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; jumonji domain containing 6; Jumonji domain-containing protein 6; KIAA0585PSR; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptorPTDSR; Protein PTDSR; PSR; PTDSR; PTDSR1 | 全称 | Jumonji Domain Containing 6/Phosphatidylserine Receptor |
| 反应种属 | Mouse |
| 应用 | Western Blot(0.1 µg/mL) |
| 目标/特异性 | Detects mouse JMJD6/PSR in Western blot. |
| 使用方法 | Western Blot: 0.1 µg/mL |
| 来源 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 23210 (Human); 107817 (Mouse); 360665 (Rat) |
| 纯化方式 | Antigen Affinity-purified |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant mouse JMJD6/PSR Ala289-Arg403 Accession # Q9ERI5 |
| 生物活性 | Mouse |
| 标记 | Biotin |
| 溶解方法 | Reconstitute at 0.2 mg/mL in sterile PBS. |
| 背景 | JMJD6 (Jumonji [Japanese for “cruciform/cross”] domain-containing protein 6; also PTDSR/PSR and Lysyl-hydroxylase JMJD6) is a 47-55 kDa member of the JMJD6 family, cupin superfamily of proteins. It is induced by hypoxia, and expressed in skeletal muscle, macrophages, and possibly endothelial cells. JMJD6 has been reported to demethylate histones, although this is now considered unlikely. It was also initially reported to serve as a phosphatidyl serine receptor, but the data regarding this activity is conflicting. What does seem clear is that JMJD6 acts as a lysyl hydroxylase. In the nucleus, it appears to regulate pre-RNA splicing by hydroxylating various splicing factors such as U2AF65. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 |
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